IPOs 2022 (US BIOTECH)

Last Update: Nov 25, 2022

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Company Drugs, Targets, Platforms Therapeutic Areas, Indications Lead Phase
Curative Biotechnology, Inc.Oligodeoxynucleotide, Anti-CD56 ADC, metformin reformulationRabies, COVID-19, Glioblastoma, Age-related macular degenerationI/II
Bullfrog AI Holdings, Inc.Mebendazole formulation, siRNA targeting Beta2-spectrinGlioblastoma, HCC, morbid obesity, NASH, NAFLD, CRCI+
Acrivon Therapeutics, Inc.CHK1/CHK2, WEE1, PKMYT1 inhibitorsCancer (Ovarian, Endometrial, Bladder, HPV+ SCC)II
Clearmind Medicine Inc.MEAI (5-Methoxy-2-aminoindane)Alcohol Use Disorder, Binge Eating, Depression, TRDPreclin
Intensity Therapeutics, Inc.Cisplatin/Vinblastine combined with SHAO (amphiphilic cell penetration enhancer)Oncology: STS, Breast, CRC, Bile Duct, Pancreatic, Squamous cell, Sarcoma, Hepatic, TNBC (neoadjuvant & metastatic)III
Prime Medicine, Inc.Ex-vivo, LNP, AAV delivered Prime Editing technologySCD, Chronic Granulomatous Disease, Cystic Fibrosis, Wilson's Disease, GSD1b, Retinitis Pigmentosa, Usher Syndrome, GJB2 Hearing Loss, Friedreich's Ataxia, DM1, ALS, DMD, Oculopharyngeal muscular dystrophy, Fragile X Syndrome, Huntington's DiseaseDisc
Alopexx, Inc.Anti-PNAG mAb, synthetic PNAG (vaccine)ICU infections, prevention of infection after emergency abdominal surgery/traumaI+
Third Harmonic Bio, Inc.KIT inhibitorChronic inducible urticaria, chronic spontaneous urticariaIa
Jupiter Neurosciences, Inc.Resveratrol in patented micellar preparationFriedreich's Ataxia, Early Alzheimer's, MPS Type I, MELAS, ALS, Traumatic brain injury/concussionII
Shuttle PharmaceuticalsRadiation therapy sensitizers, HDAC inhibitorsSarcoma, rectal cancer, proton therapy, pancreatic, BCI+
PaxMedica, Inc.IV, intranasal formulations of suraminLong COVID, Autism, Fragile X-Associated Tremor-Ataxia Syndrome (FXTAS)IIb
bioAffinity Technologies, Inc.Lung cancer diagnostic, siRNAs (CD320, LRP2)OncologyDisc
AinosLow dose oral IFN-a, RNA vaccineSjogren's Syndrome, Thrombocytopenia, COVIDIII
MAIA BiotechnologyTelomere targeting agentsNSCLC, CRC, HCC, SCLCII
Senti BioOff-the-shelf CAR-NK cells, gene therapy, cell therapies (regenerative medicine)AML, HCC, CRC, CEA+ solid tumors, regenerative medicinePreclin
Okyo PharmaChemerin peptide conjugate (CHEMR23/CMKLR1)Dry Eye Disease, Non-infectious anterior uveitis, allergic conjunctivitis, ocular painIND
Intrinsic MedicineSynthetic HMOs (human milk oligosaccharides)IBS-constipation & diarrhea, rheumatoid & juvenile idiopathic arthritis, atopic dermatitis, autismR&D
PepGenPeptide-conjugated oligonucleotides, Exon 51, Exon 53, Exon 44, Exon 45, DMPKDMD, DM1I
HilllevaxBivalent GI.1/GII.4 VLP-based vaccineNorovirus-related illnessII
Belite BioRBP4-retinol, RBP4Dry AMD, Stargardt Disease, NASH, T2DIII
AN2 TherapeuticsBacterial leucyl-tRNA synthetase (LeuRS) inhibitorChronic non-tuberculous mycobacterial (NTM) lung diseaseIb+
Ocean BiomedicalAngiotensin 1-7, Anit-Chi311, Chit1 inhibitor, anti-PfGARP, PfGARP inhibitor, PfSEA-1 vaccineNSCLC, GBM, pulmonary fibrosis (IPF, HPS), malaria, COVID-19I/II
Blue Water Vaccines, Inc.Universal flu vaccine, H1 pre-pandemic vaccine, Intranasal S. pneumoniae vaccine, Norovirus, Rotavirus, MalariaPrevention of infectious diseasesPreclin
TC BioPharm (Holdings) plcUnmodified allogeneic gamma-delta T cells (CAR-T)AML, COVID-19, solid/heme tumorsI+
Nuvectis Pharma, Inc.HSF1 inhibitor, SRC/YES1 kinase inhibitor, synthetic lethalityOvarian CCC, Endometrioid ovarian, ARID1a mutated advanced solid tumors, SRC kinase/YES1 kinase-driven solid tumorsI
Arcellx, INC.CAR-T (BCMA, CD123)MM, AML/MDS, Solid tumors, SCLC, HCCI
Samsara Vision, Inc."Implantable miniature telescope" medical deviceAMDMarket
Hillstream Biopharma, INC.Iron-mediated cell death (Ferroptosis) by salinomycin, PI3K-delta, HDAC6, TNF-alpha gene therapySCLC, solid tumors, sarcomasI
Vigil Neuroscience, Inc.Anti-TREM2 mAb, small molecule TREM2 agonistNeurology, ALSP, cALD, Alzheimer'sI
CinCor Pharma, Inc.Aldosterone synthase inhibitorUncontrolled Hypertension and high plasma aldosteroneII
Amylyx Pharmaceuticals, Inc. Sodium phenylbutyrate/taurursodiolALS, Alzheimer's, Wolfram syndromeNDA