Last Update: May 6, 2022
| Company | Drugs, Targets, Platforms | Indications | Lead Phase |
|---|---|---|---|
| Intrinsic Medicine | Synthetic HMOs (human milk oligosaccharides) | IBS-constipation & diarrhea, rheumatoid & juvenile idiopathic arthritis, atopic dermatitis, autism spectrum disorder | R&D |
| PepGen | Peptide-conjugated oligonucleotides, Exon 51, Exon 53, Exon 44, Exon 45, DMPK | DMD, DM1 | I |
| Hilllevax | Bivalent GI.1/GII.4 VLP-based vaccine | Norovirus-related illness | II |
| Belite Bio | RBP4-retinol, RBP4 | Dry AMD, Stargardt Disease, NASH, T2D | III |
| AN2 Therapeutics | Bacterial leucyl-tRNA synthetase (LeuRS) inhibitor | Chronic non-tuberculous mycobacterial (NTM) lung disease | Ib+ |
| Ocean Biomedical | Angiotensin 1-7, Anit-Chi311, Chit1 inhibitor, anti-PfGARP, PfGARP inhibitor, PfSEA-1 vaccine | NSCLC, GBM, pulmonary fibrosis (IPF, HPS), malaria, COVID-19 | I/II |
| Blue Water Vaccines, Inc. | Universal flu vaccine, H1 pre-pandemic vaccine, Intranasal S. pneumoniae vaccine, Norovirus/Rotavirus, Norovirus/Malaria | Prevention of infectious diseases | Preclin |
| Jupiter Neurosciences, Inc. | Resveratrol in patented micellar preparation | Friedreich's Ataxia, Early Alzheimer's, MPS Type I, MELAS, ALS, Traumatic brain injury/concussion | II |
| TC BioPharm (Holdings) plc | Unmodified allogeneic gamma-delta T cells (CAR-T) | AML, COVID-19, solid/heme tumors | I+ |
| Nuvectis Pharma, Inc. | HSF1 inhibitor, SRC/YES1 kinase inhibitor, synthetic lethality | Ovarian CCC, Endometrioid ovarian, ARID1a mutated advanced solid tumors, SRC kinase/YES1 kinase-driven solid tumors | I |
| Arcellx, INC. | CAR-T (BCMA, CD123) | MM, AML/MDS, Solid tumors, SCLC, HCC | I |
| Samsara Vision, Inc. | "Implantable miniature telescope" medical device | AMD | Marketed |
| Hillstream Biopharma, INC. | Iron-mediated cell death (Ferroptosis) by salinomycin, PI3K-delta, HDAC6, TNF-alpha gene therapy | SCLC, solid tumors, sarcomas | I |
| Vigil Neuroscience, Inc. | Anti-TREM2 mAb, small molecule TREM2 agonist | Neurology, ALSP, cALD, Alzheimer's | I |
| CinCor Pharma, Inc. | Aldosterone synthase inhibitor | Uncontrolled Hypertension and high plasma aldosterone | II |
| Amylyx Pharmaceuticals, Inc. | Sodium phenylbutyrate/taurursodiol | ALS, Alzheimer's, Wolfram syndrome | NDA/MAA |
| Company | Drugs, Targets, Platforms | Indications |
|---|---|---|
| Intrinsic Medicine | Synthetic HMOs (human milk oligosaccharides) | IBS-constipation & diarrhea, rheumatoid & juvenile idiopathic arthritis, atopic dermatitis, autism spectrum disorder |
| PepGen | Peptide-conjugated oligonucleotides, Exon 51, Exon 53, Exon 44, Exon 45, DMPK | DMD, DM1 |
| Hilllevax | Bivalent GI.1/GII.4 VLP-based vaccine | Norovirus-related illness |
| Belite Bio | RBP4-retinol, RBP4 | Dry AMD, Stargardt Disease, NASH, T2D |
| AN2 Therapeutics | Bacterial leucyl-tRNA synthetase (LeuRS) inhibitor | Chronic non-tuberculous mycobacterial (NTM) lung disease |
| Ocean Biomedical | Angiotensin 1-7, Anit-Chi311, Chit1 inhibitor, anti-PfGARP, PfGARP inhibitor, PfSEA-1 vaccine | NSCLC, GBM, pulmonary fibrosis (IPF, HPS), malaria, COVID-19 |
| Blue Water Vaccines, Inc. | Universal flu vaccine, H1 pre-pandemic vaccine, Intranasal S. pneumoniae vaccine, Norovirus/Rotavirus, Norovirus/Malaria | Prevention of infectious diseases |
| Jupiter Neurosciences, Inc. | Resveratrol in patented micellar preparation | Friedreich's Ataxia, Early Alzheimer's, MPS Type I, MELAS, ALS, Traumatic brain injury/concussion |
| TC BioPharm (Holdings) plc | Unmodified allogeneic gamma-delta T cells (CAR-T) | AML, COVID-19, solid/heme tumors |
| Nuvectis Pharma, Inc. | HSF1 inhibitor, SRC/YES1 kinase inhibitor, synthetic lethality | Ovarian CCC, Endometrioid ovarian, ARID1a mutated advanced solid tumors, SRC kinase/YES1 kinase-driven solid tumors |
| Arcellx, INC. | CAR-T (BCMA, CD123) | MM, AML/MDS, Solid tumors, SCLC, HCC |
| Samsara Vision, Inc. | "Implantable miniature telescope" medical device | AMD |
| Hillstream Biopharma, INC. | Iron-mediated cell death (Ferroptosis) by salinomycin, PI3K-delta, HDAC6, TNF-alpha gene therapy | SCLC, solid tumors, sarcomas |
| Vigil Neuroscience, Inc. | Anti-TREM2 mAb, small molecule TREM2 agonist | Neurology, ALSP, cALD, Alzheimer's |
| CinCor Pharma, Inc. | Aldosterone synthase inhibitor | Uncontrolled Hypertension and high plasma aldosterone |
| Amylyx Pharmaceuticals, Inc. | Sodium phenylbutyrate/taurursodiol | ALS, Alzheimer's, Wolfram syndrome |
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