IPOs 2022 (US BIOTECH)

Last Update: July 26, 2022

Company Drugs, Targets, Platforms Indications Lead Phase
MAIA BiotechnologyTelomere targeting agentsNSCLC, CRC, HCC, SCLCII
Senti BioOff-the-shelf CAR-NK cells, gene therapy, cell therapies (regenerative medicine)AML, HCC, CRC, CEA+ solid tumors, regenerative medicinePreclin
Okyo PharmaChemerin peptide conjugate (CHEMR23/CMKLR1)Dry eye disease, Non-infectious anterior uveitis, allergic conjunctivitis, ocular painIND
Intrinsic MedicineSynthetic HMOs (human milk oligosaccharides)IBS-constipation & diarrhea, rheumatoid & juvenile idiopathic arthritis, atopic dermatitis, autism spectrum disorderR&D
PepGenPeptide-conjugated oligonucleotides, Exon 51, Exon 53, Exon 44, Exon 45, DMPKDMD, DM1I
HilllevaxBivalent GI.1/GII.4 VLP-based vaccineNorovirus-related illnessII
Belite BioRBP4-retinol, RBP4Dry AMD, Stargardt Disease, NASH, T2DIII
AN2 TherapeuticsBacterial leucyl-tRNA synthetase (LeuRS) inhibitorChronic non-tuberculous mycobacterial (NTM) lung diseaseIb+
Ocean BiomedicalAngiotensin 1-7, Anit-Chi311, Chit1 inhibitor, anti-PfGARP, PfGARP inhibitor, PfSEA-1 vaccineNSCLC, GBM, pulmonary fibrosis (IPF, HPS), malaria, COVID-19I/II
Blue Water Vaccines, Inc.Universal flu vaccine, H1 pre-pandemic vaccine, Intranasal S. pneumoniae vaccine, Norovirus/Rotavirus, Norovirus/MalariaPrevention of infectious diseasesPreclin
Jupiter Neurosciences, Inc.Resveratrol in patented micellar preparationFriedreich's Ataxia, Early Alzheimer's, MPS Type I, MELAS, ALS, Traumatic brain injury/concussionII
TC BioPharm (Holdings) plcUnmodified allogeneic gamma-delta T cells (CAR-T)AML, COVID-19, solid/heme tumorsI+
Nuvectis Pharma, Inc.HSF1 inhibitor, SRC/YES1 kinase inhibitor, synthetic lethalityOvarian CCC, Endometrioid ovarian, ARID1a mutated advanced solid tumors, SRC kinase/YES1 kinase-driven solid tumorsI
Arcellx, INC.CAR-T (BCMA, CD123)MM, AML/MDS, Solid tumors, SCLC, HCCI
Samsara Vision, Inc."Implantable miniature telescope" medical deviceAMDMarket
Hillstream Biopharma, INC.Iron-mediated cell death (Ferroptosis) by salinomycin, PI3K-delta, HDAC6, TNF-alpha gene therapySCLC, solid tumors, sarcomasI
Vigil Neuroscience, Inc.Anti-TREM2 mAb, small molecule TREM2 agonistNeurology, ALSP, cALD, Alzheimer'sI
CinCor Pharma, Inc.Aldosterone synthase inhibitorUncontrolled Hypertension and high plasma aldosteroneII
Amylyx Pharmaceuticals, Inc.Sodium phenylbutyrate/taurursodiolALS, Alzheimer's, Wolfram syndromeNDA/MAA
Company Drugs, Targets, Platforms Indications
MAIA BiotechnologyTelomere targeting agentsNSCLC, CRC, HCC, SCLC
Senti BioOff-the-shelf CAR-NK cells, gene therapy, cell therapies (regenerative medicine)AML, HCC, CRC, CEA+ solid tumors, regenerative medicine
Okyo PharmaChemerin peptide conjugate (CHEMR23/CMKLR1)Dry eye disease, Non-infectious anterior uveitis, allergic conjunctivitis, ocular pain
Intrinsic MedicineSynthetic HMOs (human milk oligosaccharides)IBS-constipation & diarrhea, rheumatoid & juvenile idiopathic arthritis, atopic dermatitis, autism spectrum disorder
PepGenPeptide-conjugated oligonucleotides, Exon 51, Exon 53, Exon 44, Exon 45, DMPKDMD, DM1
HilllevaxBivalent GI.1/GII.4 VLP-based vaccineNorovirus-related illness
Belite BioRBP4-retinol, RBP4Dry AMD, Stargardt Disease, NASH, T2D
AN2 TherapeuticsBacterial leucyl-tRNA synthetase (LeuRS) inhibitorChronic non-tuberculous mycobacterial (NTM) lung disease
Ocean BiomedicalAngiotensin 1-7, Anit-Chi311, Chit1 inhibitor, anti-PfGARP, PfGARP inhibitor, PfSEA-1 vaccineNSCLC, GBM, pulmonary fibrosis (IPF, HPS), malaria, COVID-19
Blue Water Vaccines, Inc.Universal flu vaccine, H1 pre-pandemic vaccine, Intranasal S. pneumoniae vaccine, Norovirus/Rotavirus, Norovirus/MalariaPrevention of infectious diseases
Jupiter Neurosciences, Inc.Resveratrol in patented micellar preparationFriedreich's Ataxia, Early Alzheimer's, MPS Type I, MELAS, ALS, Traumatic brain injury/concussion
TC BioPharm (Holdings) plcUnmodified allogeneic gamma-delta T cells (CAR-T)AML, COVID-19, solid/heme tumors
Nuvectis Pharma, Inc.HSF1 inhibitor, SRC/YES1 kinase inhibitor, synthetic lethalityOvarian CCC, Endometrioid ovarian, ARID1a mutated advanced solid tumors, SRC kinase/YES1 kinase-driven solid tumors
Arcellx, INC.CAR-T (BCMA, CD123)MM, AML/MDS, Solid tumors, SCLC, HCC
Samsara Vision, Inc."Implantable miniature telescope" medical deviceAMD
Hillstream Biopharma, INC.Iron-mediated cell death (Ferroptosis) by salinomycin, PI3K-delta, HDAC6, TNF-alpha gene therapySCLC, solid tumors, sarcomas
Vigil Neuroscience, Inc.Anti-TREM2 mAb, small molecule TREM2 agonistNeurology, ALSP, cALD, Alzheimer's
CinCor Pharma, Inc.Aldosterone synthase inhibitorUncontrolled Hypertension and high plasma aldosterone
Amylyx Pharmaceuticals, Inc.Sodium phenylbutyrate/taurursodiolALS, Alzheimer's, Wolfram syndrome

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