Last Update: Aug 22, 2023 | Companies listed: 13
| Company | Drugs, Targets, Platforms | Therapeutic Areas, Indications | Lead Phase |
|---|---|---|---|
| Vitro Biopharma | Stem cell therapy (MSCs) | Pitt Hopkins (PTHS), Long COVID (PASC), Lupus/SLE, Multiple sclerosis, Alzheimer's | I/IIa |
| MIRA Pharmaceuticals, Inc. | THC analog (CB1/CB2) | Anxiety, Cognitive decline in early-stage dementia, chronic pain | IND |
| Turnstone Biologics Corp. | Tumor infiltrating lymphocyte therapies | Breast cancer, CRC, Uveal melanoma, Melanomas, Solid tumors | I |
| Sagimet Biosciences Inc. | FASN inhibitors | NASH, Acne, oncology (glioblastoma, FASN-dependent CRPC, HCC) | IIb |
| Apogee Therapeutics | Anti-IL-13, Anti-IL-4Ra, Anti-OX40L half-life extended antibodies | Atopic dermatitis, Asthma, COPD | I |
| 60 Degrees Pharmaceuticals, Inc. | Tafenoquine (8-aminoquinoline), Celgosivir (glucosidase inhibitor) | Malaria prevention, COVID-19, Babesiosis, Candidiasis, & Fungal Pneumonias, Dengue | C |
| Azitra Inc. | Genetically modified S. epidermidis strains, hFLG-CPP fusion protein | Netherton syndrome, cancer therapy-associated rash, Ichthyosis vulgaris | I |
| Acelyrin, Inc. | Anti-IL-17A mAb, Anti-IGF-1R mAb, Anti-C-KIT mAb | Hidradenitis Suppurativa, Psoriatic Arthritis, Axial Spondyloarthritis, Uveitis, Thyroid Eye Disease, Chronic Urticaria | III |
| CytoMed Therapeutics Limited | CAR-γδ T cell therapy, γδ T cell therapy, iPSC-derived γδ NKT cell therapy | Cancer | IND |
| Mineralys Therapeutics, Inc. | Aldosterone synthase inhibitor | Uncontrolled or resistant hypertension (uHTN, rHTN) | II+ |
| Structure Therapeutics Inc. | LPA1R, APJR, GLP-1R | Type 2 Diabetes & Obesity, Cardiopulmonary diseases, IPF | I |
| Genelux Corporation | Oncolytic virus immunotherapy (vaccinia virus), vaccine-enhanced adoptive cell therapy | Ovarian cancer, NSCLC, SCLC, Pancreatic | III |
| Cadrenal Therapeutics, Inc. | Vitamin K antagonist (VKA) | End-stage Renal Disease and Atrial Fibrilization (ESRD + AFib) | III |
Exclusions: Medical Devices, Diagnostics & Research, Medical Instruments & Supplies, Generic Drug Manufacturers. Lead phase; most advanced product/candidate. C; commercial-stage.